G Protein–Coupled Receptor (GPCR) Expression in Native Cells: “Novel” endoGPCRs as Physiologic Regulators and Therapeutic Targets

G protein–coupled receptors (GPCRs), the largest family of signaling receptors in the human genome, are also the largest class of targets of approved drugs. Are the optimal GPCRs (in terms of efficacy and safety) currently targeted therapeutically? Especially given the large number (∼120) of orphan...

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Pubblicato in:Mol Pharmacol
Autori principali: Insel, Paul A., Wilderman, Andrea, Zambon, Alexander C., Snead, Aaron N., Murray, Fiona, Aroonsakool, Nakon, McDonald, Daniel S., Zhou, Shu, McCann, Thalia, Zhang, Lingzhi, Sriram, Krishna, Chinn, Amy M., Michkov, Alexander V., Lynch, Rebecca M., Overland, Aaron C., Corriden, Ross
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2015
Soggetti:
Special Issue Commemorating the 50th Anniversary of Molecular Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468643/
https://ncbi.nlm.nih.gov/pubmed/25737495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098129
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