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C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K(+) Channels to RPR260243-Induced Slow Deactivation
Compounds can activate human ether-à-go-go–related gene 1 (hERG1) channels by several different mechanisms, including a slowing of deactivation, an increase in single channel open probability, or a reduction in C-type inactivation. The first hERG1 activator to be discovered, RPR260243 ((3R,4R)-4-[3-...
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| Gepubliceerd in: | Mol Pharmacol |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468633/ https://ncbi.nlm.nih.gov/pubmed/25888115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098384 |
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