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Differences in Methadone Metabolism by CYP2B6 Variants

Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). Retrospective studies su...

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Publicado en:Drug Metab Dispos
Autores principales: Gadel, Sarah, Friedel, Christina, Kharasch, Evan D.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468442/
https://ncbi.nlm.nih.gov/pubmed/25897175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.064352
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