Dehydro-β-proline Containing α(4)β(1) Integrin Antagonists: Stereochemical Recognition in Ligand–Receptor Interplay

[Image: see text] A novel class of dehydro-β-proline-containing peptidomimetics, designed to be effective as α(4)β(1) integrin ligands, has been developed on the basis of the fundamental requirements for the interactions of these transmembrane receptors with bioactive ligands. Dehydro-β-proline ring...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Tolomelli, Alessandra, Baiula, Monica, Viola, Angelo, Ferrazzano, Lucia, Gentilucci, Luca, Dattoli, Samantha Deianira, Spampinato, Santi, Juaristi, Eusebio, Escudero, Margarita
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468404/
https://ncbi.nlm.nih.gov/pubmed/26101577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00125
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