Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [(11)C]ITMM with Ultra-High Specific Activity in Small-Animal PET

Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial target in the development of new medications to treat central nervous system (CNS) disorders. Recently, we developed N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-[(11)C]methoxy-N-methyl-benzamide ([(11)C]ITMM) as a useful...

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Udgivet i:PLoS One
Main Authors: Yamasaki, Tomoteru, Fujinaga, Masayuki, Yui, Joji, Wakizaka, Hidekatsu, Ohya, Tomoyuki, Nengaki, Nobuki, Ogawa, Masanao, Ikoma, Yoko, Hatori, Akiko, Xie, Lin, Kawamura, Kazunori, Zhang, Ming-Rong
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468202/
https://ncbi.nlm.nih.gov/pubmed/26076143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130006
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