Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1

Loss of hematopoietic stem cell (HSC) function and increased risk of developing hematopoietic malignancies are severe and concerning complications of anticancer radiotherapy and chemotherapy. We have previously shown that thrombopoietin (TPO), a critical HSC regulator, ensures HSC chromosomal integr...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: de Laval, Bérengère, Pawlikowska, Patrycja, Barbieri, Daniela, Besnard-Guerin, Corinne, Cico, Alba, Kumar, Rajiv, Gaudry, Murielle, Baud, Véronique, Porteu, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467873/
https://ncbi.nlm.nih.gov/pubmed/24184684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-515874
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