Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is becoming a pandemic. While multiple ‘hits’ have been reported to contribute to NAFLD progression to non-alcoholic steatohepatitis (NASH), fibrosis and liver cancer, understanding the natural history of the specific molecular signals leading to...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Ganz, Michal, Bukong, Terence N, Csak, Timea, Saha, Banishree, Park, Jin-Kyu, Ambade, Aditya, Kodys, Karen, Szabo, Gyongyi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467677/
https://ncbi.nlm.nih.gov/pubmed/26077675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0552-7
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