Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4–nuclear factor kappa B signaling

BACKGROUND: To investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI) in an orthotopic autologous liver transplantation (OALT) rat model and to explore the mechanisms responsible for the protective effect of Dex against lung injury. METHOD...

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Udgivet i:J Transl Med
Main Authors: Chi, Xinjin, Wei, Xiaoxia, Gao, Wanling, Guan, Jianqiang, Yu, Xiaofan, Wang, Yiheng, Li, Xi, Cai, Jun
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467671/
https://ncbi.nlm.nih.gov/pubmed/26070954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0554-5
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