Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats

Patients who undergo orthotopic liver transplantation often sustain acute kidney injury(AKI). The toll-like receptor 4(TLR4)/Nuclear factor-кB(NF-кB) pathway plays a role in AKI. Dexmedetomidine(Dex) has been shown to attenuate AKI. The current study aimed to determine whether liver transplantation-...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Yao, Hui, Chi, Xinjin, Jin, Yi, Wang, Yiheng, Huang, Pinjie, Wu, Shan, Xia, Zhengyuan, Cai, Jun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653646/
https://ncbi.nlm.nih.gov/pubmed/26585410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16849
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