The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines

BACKGROUND: Increased expression of the epidermal growth factor receptor (EGFR) is observed in more than 90% of all head and neck squamous cell carcinomas (HNSCC). Therefore, EGFR has emerged as a promising therapeutic target. Nevertheless, drug resistance remains a major challenge and an important...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Res Notes
Main Authors: Boeckx, Carolien, Van den Bossche, Jolien, De Pauw, Ines, Peeters, Marc, Lardon, Filip, Baay, Marc, Wouters, An
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Short Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467624/
https://ncbi.nlm.nih.gov/pubmed/26032726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13104-015-1197-6
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