Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

As a conserved protein interaction module that recognizes and binds to acetylated lysine, bromodomain (BRD) contains a deep, largely hydrophobic acetyl lysine binding site. Proteins that share the feature of containing two BRDs and an extra-terminal domain belong to BET family, including BRD2, BRD3,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fu, Lei-lei, Tian, Mao, Li, Xiang, Li, Jing-jing, Huang, Jian, Ouyang, Liang, Zhang, Yonghui, Liu, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467383/
https://ncbi.nlm.nih.gov/pubmed/25849938
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