Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

In vivo functional investigation of oncogenes using somatic gene transfer has been successfully exploited to validate their role in tumorigenesis. For tumour suppressor genes this has proven more challenging due to technical aspects. To provide a flexible and effective method for investigating somat...

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Vydáno v:Nat Commun
Hlavní autoři: Zuckermann, Marc, Hovestadt, Volker, Knobbe-Thomsen, Christiane B., Zapatka, Marc, Northcott, Paul A., Schramm, Kathrin, Belic, Jelena, Jones, David T. W., Tschida, Barbara, Moriarity, Branden, Largaespada, David, Roussel, Martine F., Korshunov, Andrey, Reifenberger, Guido, Pfister, Stefan M., Lichter, Peter, Kawauchi, Daisuke, Gronych, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467376/
https://ncbi.nlm.nih.gov/pubmed/26067104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8391
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