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Effects of Ketoconazole on the Pharmacokinetics of Lenvatinib (E7080) in Healthy Participants
BACKGROUND: Lenvatinib is an oral, multitargeted, tyrosine kinase inhibitor under clinical investigation in solid tumors. In vitro evidence indicates that lenvatinib metabolism may be modulated by ketoconazole, an inhibitor of CYP3A4 and p-glycoprotein. METHODS: In this Phase I, single-center, rando...
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| Publicado no: | Clin Pharmacol Drug Dev |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4467237/ https://ncbi.nlm.nih.gov/pubmed/26097795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.140 |
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