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Effect of Rifampicin on the Pharmacokinetics of Lenvatinib in Healthy Adults
BACKGROUND AND OBJECTIVES: Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor under clinical investigation in solid tumours. This study evaluated the influence of P-glycoprotein (P-gp) inhibition (single-dose rifampicin) and simultaneous cytochrome P450 3A4 (CYP3A4)/P-gp induction (multi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer International Publishing
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4143598/ https://ncbi.nlm.nih.gov/pubmed/25022720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40261-014-0217-y |
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