Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

Chimeric antigen receptors (CARs) are synthetic molecules designed to redirect T cells to specific antigens. CAR-modified T cells can mediate long-term durable remissions in B cell malignancies, but expanding this platform to solid tumors requires the discovery of surface targets with limited expres...

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Udgivet i:Sci Transl Med
Main Authors: Johnson, Laura A., Scholler, John, Ohkuri, Takayuki, Kosaka, Akemi, Patel, Prachi R., McGettigan, Shannon E., Nace, Arben K., Dentchev, Tzvete, Thekkat, Pramod, Loew, Andreas, Boesteanu, Alina C., Cogdill, Alexandria P., Chen, Taylor, Fraietta, Joseph A., Kloss, Christopher C., Posey, Avery D., Engels, Boris, Singh, Reshma, Ezell, Tucker, Idamakanti, Neeraja, Ramones, Melissa H., Li, Na, Zhou, Li, Plesa, Gabriela, Seykora, John T., Okada, Hideho, June, Carl H., Brogdon, Jennifer L., Maus, Marcela V.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467166/
https://ncbi.nlm.nih.gov/pubmed/25696001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa4963
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