Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

Chimeric antigen receptors (CARs) are synthetic molecules designed to redirect T cells to specific antigens. CAR-modified T cells can mediate long-term durable remissions in B cell malignancies, but expanding this platform to solid tumors requires the discovery of surface targets with limited expres...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Johnson, Laura A., Scholler, John, Ohkuri, Takayuki, Kosaka, Akemi, Patel, Prachi R., McGettigan, Shannon E., Nace, Arben K., Dentchev, Tzvete, Thekkat, Pramod, Loew, Andreas, Boesteanu, Alina C., Cogdill, Alexandria P., Chen, Taylor, Fraietta, Joseph A., Kloss, Christopher C., Posey, Avery D., Engels, Boris, Singh, Reshma, Ezell, Tucker, Idamakanti, Neeraja, Ramones, Melissa H., Li, Na, Zhou, Li, Plesa, Gabriela, Seykora, John T., Okada, Hideho, June, Carl H., Brogdon, Jennifer L., Maus, Marcela V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467166/
https://ncbi.nlm.nih.gov/pubmed/25696001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa4963
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados