PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers. PARP-1 is a nuclear protein involved in multiple facets of DNA repair and transcriptional regulation. In this study we dissected the action of PARP inhibition in different GBM cell...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Majuelos-Melguizo, Jara, Rodríguez, María Isabel, López-Jiménez, Laura, Rodríguez-Vargas, Jose M., Martí Martín-Consuegra, Juan M., Serrano-Sáenz, Santiago, Gavard, Julie, Mariano Ruiz de Almodóvar, J, Javier Oliver, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467115/
https://ncbi.nlm.nih.gov/pubmed/25576921
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