ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

In response to nutrient stress, cells start an autophagy program that can lead to adaptation or death. The mechanisms underlying the signaling from starvation to the initiation of autophagy are not fully understood. In the current study we show that the absence or inactivation of PARP-1 strongly del...

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Detalhes bibliográficos
Main Authors: Rodríguez-Vargas, José Manuel, Ruiz-Magaña, María José, Ruiz-Ruiz, Carmen, Majuelos-Melguizo, Jara, Peralta-Leal, Andreína, Rodríguez, María Isabel, Muñoz-Gámez, José Antonio, de Almodóvar, Mariano Ruiz, Siles, Eva, Rivas, Abelardo López, Jäättela, Marja, Oliver, F Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391023/
https://ncbi.nlm.nih.gov/pubmed/22525338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.70
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