ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

In response to nutrient stress, cells start an autophagy program that can lead to adaptation or death. The mechanisms underlying the signaling from starvation to the initiation of autophagy are not fully understood. In the current study we show that the absence or inactivation of PARP-1 strongly del...

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Autors principals: Rodríguez-Vargas, José Manuel, Ruiz-Magaña, María José, Ruiz-Ruiz, Carmen, Majuelos-Melguizo, Jara, Peralta-Leal, Andreína, Rodríguez, María Isabel, Muñoz-Gámez, José Antonio, de Almodóvar, Mariano Ruiz, Siles, Eva, Rivas, Abelardo López, Jäättela, Marja, Oliver, F Javier
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391023/
https://ncbi.nlm.nih.gov/pubmed/22525338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.70
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