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BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

B-cell lymphoma 2 (BCL-2) ovarian killer (BOK) is a BCL-2 family protein with high homology to the multidomain proapoptotic proteins BAX and BAK, yet Bok(−/−) and even Bax(−/−)Bok(−/−) and Bak(−/−)Bok(−/−) mice were reported to have no overt phenotype or apoptotic defects in response to a host of cl...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Carpio, Marcos A., Michaud, Michael, Zhou, Wenping, Fisher, Jill K., Walensky, Loren D., Katz, Samuel G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466744/
https://ncbi.nlm.nih.gov/pubmed/26015568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421063112
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