hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function

We report that mice lacking the heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the heart develop lethal dilated cardiomyopathy and display numerous defects in cardiac pre-mRNA splicing. Mutant hearts have disorganized cardiomyocytes, impaired contractility, and abnormal excitation–contractio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ye, Junqiang, Beetz, Nadine, O’Keeffe, Sean, Tapia, Juan Carlos, Macpherson, Lindsey, Chen, Weisheng V., Bassel-Duby, Rhonda, Olson, Eric N., Maniatis, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466706/
https://ncbi.nlm.nih.gov/pubmed/26039991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508461112
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