Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases

The infectious agents of the transmissible spongiform encephalopathies are composed of amyloidogenic prion protein, PrP(Sc). Real-time quaking-induced conversion can amplify very small amounts of PrP(Sc) seeds in tissues/body fluids of patients or animals. Using this in vitro PrP-amyloid amplificati...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Takatsuki, Hanae, Satoh, Katsuya, Sano, Kazunori, Fuse, Takayuki, Nakagaki, Takehiro, Mori, Tsuyoshi, Ishibashi, Daisuke, Mihara, Ban, Takao, Masaki, Iwasaki, Yasushi, Yoshida, Mari, Atarashi, Ryuichiro, Nishida, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466537/
https://ncbi.nlm.nih.gov/pubmed/26070208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126930
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