Seneca Valley Virus 3C(pro) Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy

The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-001 virotherapy with a peptide prodrug activa...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Miles, Linde A., Brennen, W. Nathaniel, Rudin, Charles M., Poirier, John T.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466507/
https://ncbi.nlm.nih.gov/pubmed/26069962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129103
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