Modulation of L-DOPA’s antiparkinsonian and dyskinetic effects by α2-noradrenergic receptors within the locus coeruleus

Long-term L-DOPA use for Parkinson’s disease (PD) is frequently complicated by the emergence of a debilitating motor side effect known as L-DOPA-induced dyskinesia (LID). Accumulating evidence has implicated the norepinephrine (NE) system in the pathogenesis of LID. Here we used the unilateral 6-hyd...

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發表在:Neuropharmacology
Main Authors: Ostock, Corinne Y, Hallmark, Joy, Palumbo, Noel, Bhide, Nirmal, Conti, Melissa, George, Jessica A, Bishop, Christopher
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466080/
https://ncbi.nlm.nih.gov/pubmed/25817388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.03.008
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