Effects of noradrenergic denervation by anti-DBH-saporin on behavioral responsivity to L-DOPA in the hemi-parkinsonian rat

Dopamine (DA) replacement with L-DOPA remains the most effective pharmacotherapy for motor symptoms of Parkinson’s disease (PD) including tremor, postural instability, akinesia, and bradykinesia. Prolonged L-DOPA use frequently leads to deleterious side effects including involuntary choreic and dyst...

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Autori principali: Ostock, Corinne Y., Lindenbach, David, Goldenberg, Adam A., Kampton, Elias, Bishop, Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103008/
https://ncbi.nlm.nih.gov/pubmed/24837745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2014.05.009
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