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Epigenetic changes in BRCA1-mutated familial breast cancer
Familial breast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. The mutated BRCA1 leads to the disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent...
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發表在: | Cancer Genet |
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Main Authors: | , |
格式: | Artigo |
語言: | Inglês |
出版: |
2015
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4466075/ https://ncbi.nlm.nih.gov/pubmed/25800897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergen.2015.02.001 |
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