Dual agonist occupancy of AT(1)-R–α(2C)-AR heterodimers results in atypical G(s)-PKA signaling

[Image: see text] Hypersecretion of norepinephrine (NE) and angiotensin II (AngII) is a hallmark of major prevalent cardiovascular diseases that contribute to cardiac pathophysiology and morbidity. Herein, we explore whether heterodimerization of presynaptic AngII AT(1) receptor (AT1-R) and NE α(2C)...

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Udgivet i:Nat Chem Biol
Main Authors: Bellot, Morgane, Galandrin, Ségolène, Boularan, Cédric, Matthies, Heinrich J, Despas, Fabien, Denis, Colette, Javitch, Jonathan, Mazères, Serge, Sanni, Samra Joke, Pons, Véronique, Seguelas, Marie-Hélène, Hansen, Jakob L, Pathak, Atul, Galli, Aurelio, Sénard, Jean-Michel, Galés, Céline
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465922/
https://ncbi.nlm.nih.gov/pubmed/25706338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1766
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