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Dual agonist occupancy of AT(1)-R–α(2C)-AR heterodimers results in atypical G(s)-PKA signaling
[Image: see text] Hypersecretion of norepinephrine (NE) and angiotensin II (AngII) is a hallmark of major prevalent cardiovascular diseases that contribute to cardiac pathophysiology and morbidity. Herein, we explore whether heterodimerization of presynaptic AngII AT(1) receptor (AT1-R) and NE α(2C)...
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| Udgivet i: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465922/ https://ncbi.nlm.nih.gov/pubmed/25706338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1766 |
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