Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease

A new human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently developed. In this model, ingestion of 104 CFU of Salmonella resulted in 65% of subjects developing typhoid fever (referred here as typhoid diagnosis -TD-) 5–10 days post-challenge. TD criteria included meeting...

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Опубликовано в: :PLoS Negl Trop Dis
Главные авторы: Toapanta, Franklin R., Bernal, Paula J., Fresnay, Stephanie, Darton, Thomas C., Jones, Claire, Waddington, Claire S., Blohmke, Christoph J., Dougan, Gordon, Angus, Brian, Levine, Myron M., Pollard, Andrew J., Sztein, Marcelo B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465829/
https://ncbi.nlm.nih.gov/pubmed/26065687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003837
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