Positive Charge of “Sticky” Peptides and Proteins Impedes Release From Negatively Charged PLGA Matrices

The influence of electrostatic interactions and/or acylation on release of charged (“sticky”) agents from biodegradable polymer matrices was systematically characterized. We hypothesized that release of peptides with positive charge would be hindered from negatively charged poly(lactic-co-glycolic a...

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Veröffentlicht in:J Mater Chem B Mater Biol Med
Hauptverfasser: Balmert, Stephen C., Zmolek, Andrew C., Glowacki, Andrew J., Knab, Timothy D., Rothstein, Sam N., Wokpetah, Joseph M., Fedorchak, Morgan V., Little, Steven R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465798/
https://ncbi.nlm.nih.gov/pubmed/26085928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5TB00515A
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