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Positive Charge of “Sticky” Peptides and Proteins Impedes Release From Negatively Charged PLGA Matrices

The influence of electrostatic interactions and/or acylation on release of charged (“sticky”) agents from biodegradable polymer matrices was systematically characterized. We hypothesized that release of peptides with positive charge would be hindered from negatively charged poly(lactic-co-glycolic a...

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Detalhes bibliográficos
Publicado no:J Mater Chem B Mater Biol Med
Main Authors: Balmert, Stephen C., Zmolek, Andrew C., Glowacki, Andrew J., Knab, Timothy D., Rothstein, Sam N., Wokpetah, Joseph M., Fedorchak, Morgan V., Little, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465798/
https://ncbi.nlm.nih.gov/pubmed/26085928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5TB00515A
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