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Destabilization of peptide: MHC interaction induces IL-2 resistant anergy in diabetogenic T cells
Autoreactive T cells are responsible for inducing several autoimmune diseases, including type 1 diabetes. We have developed a strategy to induce unresponsiveness in these cells by destabilizing the peptide:MHC ligand recognized by the T cell receptor. By introducing amino acid substitutions into the...
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| Udgivet i: | J Autoimmun |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465239/ https://ncbi.nlm.nih.gov/pubmed/23895744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.07.002 |
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