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Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state
We have performed microsecond molecular dynamics (MD) simulations and protein pK(a) calculations of the muscle calcium pump (sarcoplasmic reticulum Ca(2+)-ATPase, SERCA) in complex with sarcolipin (SLN) to determine the mechanism by which SLN inhibits SERCA. SLN and its close analogue phospholamban...
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Publicado no: | Biochem Biophys Res Commun |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465059/ https://ncbi.nlm.nih.gov/pubmed/25983321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.05.012 |
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