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Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state

We have performed microsecond molecular dynamics (MD) simulations and protein pK(a) calculations of the muscle calcium pump (sarcoplasmic reticulum Ca(2+)-ATPase, SERCA) in complex with sarcolipin (SLN) to determine the mechanism by which SLN inhibits SERCA. SLN and its close analogue phospholamban...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Espinoza-Fonseca, L. Michel, Autry, Joseph M., Thomas, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465059/
https://ncbi.nlm.nih.gov/pubmed/25983321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.05.012
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