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Sarcolipin promotes uncoupling of the SERCA Ca(2+) pump by inducing a structural rearrangement in the energy-transduction domin
We have performed μs molecular dynamics simulation (MDS) to identify structural mechanisms for sarcolipin (SLN) uncoupling of Ca(2+) transport from ATP hydrolysis for the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA). SLN regulates muscle metabolism and energy expenditure to provide resistance agains...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5506494/ https://ncbi.nlm.nih.gov/pubmed/27731980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00728 |
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