Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD. Preclinical work indicates that ‘low dose’ theophylline improves steroi...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Devereux, Graham, Cotton, Seonaidh, Barnes, Peter, Briggs, Andrew, Burns, Graham, Chaudhuri, Rekha, Chrystyn, Henry, Davies, Lisa, De Soyza, Anthony, Fielding, Shona, Gompertz, Simon, Haughney, John, Lee, Amanda J., McCormack, Kirsty, McPherson, Gladys, Morice, Alyn, Norrie, John, Sullivan, Anita, Wilson, Andrew, Price, David
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465017/
https://ncbi.nlm.nih.gov/pubmed/26058585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0782-2
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