Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial

IMPORTANCE: Chronic obstructive pulmonary disease (COPD) is a major global health issue and theophylline is used extensively. Preclinical investigations have demonstrated that low plasma concentrations (1-5 mg/L) of theophylline enhance antiinflammatory effects of corticosteroids in COPD. OBJECTIVE:...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Devereux, Graham, Cotton, Seonaidh, Fielding, Shona, McMeekin, Nicola, Barnes, Peter J., Briggs, Andrew, Burns, Graham, Chaudhuri, Rekha, Chrystyn, Henry, Davies, Lisa, De Soyza, Anthony, Gompertz, Simon, Haughney, John, Innes, Karen, Kaniewska, Joanna, Lee, Amanda, Morice, Alyn, Norrie, John, Sullivan, Anita, Wilson, Andrew, Price, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233797/
https://ncbi.nlm.nih.gov/pubmed/30326124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2018.14432
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