Reovirus FAST Proteins Drive Pore Formation and Syncytiogenesis Using a Novel Helix-Loop-Helix Fusion-Inducing Lipid Packing Sensor

Pore formation is the most energy-demanding step during virus-induced membrane fusion, where high curvature of the fusion pore rim increases the spacing between lipid headgroups, exposing the hydrophobic interior of the membrane to water. How protein fusogens breach this thermodynamic barrier to por...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Read, Jolene, Clancy, Eileen K., Sarker, Muzaddid, de Antueno, Roberto, Langelaan, David N., Parmar, Hiren B., Shin, Kyungsoo, Rainey, Jan K., Duncan, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464655/
https://ncbi.nlm.nih.gov/pubmed/26061049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004962
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