Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins

Systemic treatment with statins mitigates allergic airway inflammation, T(H)2 cytokine production, epithelial mucus production, and airway hyperreactivity (AHR) in murine models of asthma. We hypothesized that pravastatin delivered intratracheally would be quantifiable in lung tissues using mass spe...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Zeki, Amir A, Bratt, Jennifer M, Chang, Kevin Y, Franzi, Lisa M, Ott, Sean, Silveria, Mark, Fiehn, Oliver, Last, Jerold A, Kenyon, Nicholas J
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463814/
https://ncbi.nlm.nih.gov/pubmed/25969462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12352
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