Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins

Systemic treatment with statins mitigates allergic airway inflammation, T(H)2 cytokine production, epithelial mucus production, and airway hyperreactivity (AHR) in murine models of asthma. We hypothesized that pravastatin delivered intratracheally would be quantifiable in lung tissues using mass spe...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Zeki, Amir A, Bratt, Jennifer M, Chang, Kevin Y, Franzi, Lisa M, Ott, Sean, Silveria, Mark, Fiehn, Oliver, Last, Jerold A, Kenyon, Nicholas J
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463814/
https://ncbi.nlm.nih.gov/pubmed/25969462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12352
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