Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins

Systemic treatment with statins mitigates allergic airway inflammation, T(H)2 cytokine production, epithelial mucus production, and airway hyperreactivity (AHR) in murine models of asthma. We hypothesized that pravastatin delivered intratracheally would be quantifiable in lung tissues using mass spe...

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Dettagli Bibliografici
Pubblicato in:Physiol Rep
Autori principali: Zeki, Amir A, Bratt, Jennifer M, Chang, Kevin Y, Franzi, Lisa M, Ott, Sean, Silveria, Mark, Fiehn, Oliver, Last, Jerold A, Kenyon, Nicholas J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463814/
https://ncbi.nlm.nih.gov/pubmed/25969462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12352
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