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Rationale for targeting the pre–B-cell receptor signaling pathway in acute lymphoblastic leukemia

Inhibitors of B-cell receptor (BCR) and pre-BCR signaling were successfully introduced into patient care for various subtypes of mature B-cell lymphoma (eg, ibrutinib, idelalisib). Acute lymphoblastic leukemia (ALL) typically originates from pre-B cells that critically depend on survival signals ema...

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Sonraí Bibleagrafaíochta
Foilsithe in:Blood
Príomhúdar: Müschen, Markus
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463734/
https://ncbi.nlm.nih.gov/pubmed/25878119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-567842
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