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Rationale for targeting the pre–B-cell receptor signaling pathway in acute lymphoblastic leukemia
Inhibitors of B-cell receptor (BCR) and pre-BCR signaling were successfully introduced into patient care for various subtypes of mature B-cell lymphoma (eg, ibrutinib, idelalisib). Acute lymphoblastic leukemia (ALL) typically originates from pre-B cells that critically depend on survival signals ema...
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| Publié dans: | Blood |
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| Auteur principal: | |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4463734/ https://ncbi.nlm.nih.gov/pubmed/25878119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-567842 |
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