Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport

High blood urate levels (hyperuricemia) have been found to be a significant risk factor for cardiovascular diseases and inflammatory arthritis, such as hypertension and gout. Human glucose transporter 9 (hSLC2A9) is an essential protein that mainly regulates urate/hexose homeostasis in human kidney...

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Vydáno v:J Biol Chem
Hlavní autoři: Long, Wentong, Panwar, Pankaj, Witkowska, Kate, Wong, Kenneth, O'Neill, Debbie, Chen, Xing-Zhen, Lemieux, M. Joanne, Cheeseman, Chris I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463468/
https://ncbi.nlm.nih.gov/pubmed/25922070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611178
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