Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9

Matrix metalloproteases (MMPs) MMP-2 and MMP-9 have been implicated in the physiological catabolism of Alzheimer's amyloid-β (Aβ). Conversely, their association with vascular amyloid deposits, blood-brain barrier disruption, and hemorrhagic transformations after ischemic stroke also highlights...

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Vydáno v:J Biol Chem
Hlavní autoři: Hernandez-Guillamon, Mar, Mawhirt, Stephanie, Blais, Steven, Montaner, Joan, Neubert, Thomas A., Rostagno, Agueda, Ghiso, Jorge
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463451/
https://ncbi.nlm.nih.gov/pubmed/25897080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610931
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