K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells

Low density lipoprotein receptor-related protein (LRP1) mediates the internalization of aggregated LDL (AgLDL), which in turn increases the expression of LRP1 in human vascular smooth muscle cells (hVSMCs). This positive feedback mechanism is thus highly efficient to promote the formation of hVSMC f...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Costales, Paula, Fuentes-Prior, Pablo, Castellano, Jose, Revuelta-Lopez, Elena, Corral-Rodríguez, Maria Ángeles, Nasarre, Laura, Badimon, Lina, Llorente-Cortes, Vicenta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463433/
https://ncbi.nlm.nih.gov/pubmed/25918169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638361
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