K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells

Low density lipoprotein receptor-related protein (LRP1) mediates the internalization of aggregated LDL (AgLDL), which in turn increases the expression of LRP1 in human vascular smooth muscle cells (hVSMCs). This positive feedback mechanism is thus highly efficient to promote the formation of hVSMC f...

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Udgivet i:J Biol Chem
Main Authors: Costales, Paula, Fuentes-Prior, Pablo, Castellano, Jose, Revuelta-Lopez, Elena, Corral-Rodríguez, Maria Ángeles, Nasarre, Laura, Badimon, Lina, Llorente-Cortes, Vicenta
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463433/
https://ncbi.nlm.nih.gov/pubmed/25918169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638361
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