Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy

Circulating tumor cells (CTCs) are seeds for cancer metastasis and are predictive of poor prognosis in breast cancer patients. Whether CTCs and primary tumor cells (PTCs) respond to chemotherapy differently is not known. Here, we show that CTCs of breast cancer are more resistant to chemotherapy tha...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Gong, Chang, Liu, Bodu, Yao, Yandan, Qu, Shaohua, Luo, Wei, Tan, Weige, Liu, Qiang, Yao, Herui, Zou, Lee, Su, Fengxi, Song, Erwei
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463430/
https://ncbi.nlm.nih.gov/pubmed/25897074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652628
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