Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy

Circulating tumor cells (CTCs) are seeds for cancer metastasis and are predictive of poor prognosis in breast cancer patients. Whether CTCs and primary tumor cells (PTCs) respond to chemotherapy differently is not known. Here, we show that CTCs of breast cancer are more resistant to chemotherapy tha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gong, Chang, Liu, Bodu, Yao, Yandan, Qu, Shaohua, Luo, Wei, Tan, Weige, Liu, Qiang, Yao, Herui, Zou, Lee, Su, Fengxi, Song, Erwei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463430/
https://ncbi.nlm.nih.gov/pubmed/25897074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652628
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