TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts

Current strategies to alter disease-associated epigenetic modifications target ubiquitously expressed epigenetic regulators. This approach does not allow specific genes to be controlled in specific cell types; therefore, tools to selectively target epigenetic modifications in the desired cell type a...

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Publicat a:J Clin Invest
Autors principals: Bernstein, Diana L., Le Lay, John E., Ruano, Elena G., Kaestner, Klaus H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2015
Matèries:
Technical Advance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463192/
https://ncbi.nlm.nih.gov/pubmed/25866970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77321
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