Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors

Mutant mouse models are indispensable tools for clarifying gene functions and elucidating the pathogenic mechanisms of human diseases. Here, we describe novel cancer models bearing point mutations in the retinoblastoma gene (Rb1) generated by N-ethyl-N-nitrosourea mutagenesis. Two mutations in splic...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Toki, Hideaki, Inoue, Maki, Minowa, Osamu, Motegi, Hiromi, Saiki, Yuriko, Wakana, Shigeharu, Masuya, Hiroshi, Gondo, Yoichi, Shiroishi, Toshihiko, Yao, Ryoji, Noda, Tetsuo
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462357/
https://ncbi.nlm.nih.gov/pubmed/25088905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12495
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