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Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors

Mutant mouse models are indispensable tools for clarifying gene functions and elucidating the pathogenic mechanisms of human diseases. Here, we describe novel cancer models bearing point mutations in the retinoblastoma gene (Rb1) generated by N-ethyl-N-nitrosourea mutagenesis. Two mutations in splic...

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Bibliografiske detaljer
Udgivet i:Cancer Sci
Main Authors: Toki, Hideaki, Inoue, Maki, Minowa, Osamu, Motegi, Hiromi, Saiki, Yuriko, Wakana, Shigeharu, Masuya, Hiroshi, Gondo, Yoichi, Shiroishi, Toshihiko, Yao, Ryoji, Noda, Tetsuo
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462357/
https://ncbi.nlm.nih.gov/pubmed/25088905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12495
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