Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development

The vertebrate heart develops from mesoderm and requires inductive signals secreted from early endoderm. During embryogenesis, Nkx2.5 acts as a key transcription factor and plays essential roles for heart formation from Drosophila to human. In mice, Nkx2.5 is expressed in the early first heart field...

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Bibliografiske detaljer
Udgivet i:Dev Biol
Main Authors: Zhang, Lu, Nomura-Kitabayashi, Aya, Sultana, Nishat, Cai, Weibin, Cai, Xiaoqiang, Moon, Anne M., Cai, Chen-Leng
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461860/
https://ncbi.nlm.nih.gov/pubmed/24613616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.02.023
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