ERG activates the YAP1 transcriptional program and induces the development of age-related prostate tumors

Significance of ERG in human prostate cancer is unclear because mouse prostate is resistant to ERG-mediated transformation. We determined that ERG activates the transcriptional program regulated by YAP1 of the Hippo signaling pathway and found that prostate-specific activation of either ERG or YAP1...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Nguyen, Liem T., Tretiakova, Maria S., Silvis, Mark R., Lucas, Jared, Klezovitch, Olga, Coleman, Ilsa, Bolouri, Hamid, Kutyavin, Vassily I., Morrissey, Colm, True, Lawrence D., Nelson, Peter S., Vasioukhin, Valeri
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461839/
https://ncbi.nlm.nih.gov/pubmed/26058078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.05.005
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