α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1

The Hippo pathway regulates contact inhibition of cell proliferation and, ultimately, organ size in diverse multicellular organisms. Inactivation of the Hippo pathway promotes nuclear localization of the transcriptional coactivator Yap1, a Hippo pathway effector, and can cause cancer. Here, we show...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Silvis, Mark R., Kreger, Bridget T., Lien, Wen-Hui, Klezovitch, Olga, Rudakova, G. Marianna, Camargo, Fernando D., Lantz, Dan M., Seykora, John T., Vasioukhin, Valeri
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366274/
https://ncbi.nlm.nih.gov/pubmed/21610251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001823
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