α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1

The Hippo pathway regulates contact inhibition of cell proliferation and, ultimately, organ size in diverse multicellular organisms. Inactivation of the Hippo pathway promotes nuclear localization of the transcriptional coactivator Yap1, a Hippo pathway effector, and can cause cancer. Here, we show...

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Main Authors: Silvis, Mark R., Kreger, Bridget T., Lien, Wen-Hui, Klezovitch, Olga, Rudakova, G. Marianna, Camargo, Fernando D., Lantz, Dan M., Seykora, John T., Vasioukhin, Valeri
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366274/
https://ncbi.nlm.nih.gov/pubmed/21610251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001823
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